CLINICAL RESEARCH
Determinants of serum cytokines in a population sample of healthy subjects from Iran
1
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
2
Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3
Department of Anesthesia and Operating Room Nursing, Neyshabur University of Medical Sciences, Neyshabur, Iran
4
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
5
Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, UK
6
Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
8
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Submission date: 2023-08-20
Acceptance date: 2023-08-31
Publication date: 2023-09-30
Arch Med Sci Atheroscler Dis 2023;8(1):89–95
KEYWORDS
TOPICS
Clinical studies, clinical trialElderlyBiomarkersBasic researchImmunologyInflammation, oxidative stress, antioxidants
ABSTRACT
Introduction:
Cytokines are synthesized and released by immune system cells and mediate critical immune responses. Aging is associated with increased serum levels of some pro-inflammatory cytokines . A positive correlation between the concentration of several cytokines and blood pressure has been reported; higher cytokine concentrations may be related to the underlying causes of hypertension through the effects of inflammatory responses or as an independent etiology for hypertension .To assess the relationship between the serum levels of inflammatory cytokines and growth factors, with biochemical and anthropometric characteristics in healthy Iranian subjects.
Material and methods:
Anthropometric measurements and blood sampling were performed in 103 healthy Iranian participants. Fasting blood glucose (FBG), hs-CRP and lipid profile were measured in these participants. 12 serum cytokines/growth factors (MCP-1, TNF-α, EGF, IFN-γ, VEGF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10 were measured.
Results:
FBG was positively associated with serum IL-2, IL-4 and IL-1α (P = 0.044, < 0.001 and = 0.017, respectively). Serum EGF and IL-4 were positively associated with age (P < 0.001). IL-8 was inversely associated with SBP (P = 0.002) and gender (P = 0.028). There was a positive association between VEGF and HDL (P = 0.007). The serum levels of IFN-γ and TNF-α were positively associated with serum TG (P = 0.018 and 0.006, respectively).
Conclusions:
There are associations between various pro-and anti-inflammatory cytokines in serum and several anthropometric measurements.
Cytokines are synthesized and released by immune system cells and mediate critical immune responses. Aging is associated with increased serum levels of some pro-inflammatory cytokines . A positive correlation between the concentration of several cytokines and blood pressure has been reported; higher cytokine concentrations may be related to the underlying causes of hypertension through the effects of inflammatory responses or as an independent etiology for hypertension .To assess the relationship between the serum levels of inflammatory cytokines and growth factors, with biochemical and anthropometric characteristics in healthy Iranian subjects.
Material and methods:
Anthropometric measurements and blood sampling were performed in 103 healthy Iranian participants. Fasting blood glucose (FBG), hs-CRP and lipid profile were measured in these participants. 12 serum cytokines/growth factors (MCP-1, TNF-α, EGF, IFN-γ, VEGF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10 were measured.
Results:
FBG was positively associated with serum IL-2, IL-4 and IL-1α (P = 0.044, < 0.001 and = 0.017, respectively). Serum EGF and IL-4 were positively associated with age (P < 0.001). IL-8 was inversely associated with SBP (P = 0.002) and gender (P = 0.028). There was a positive association between VEGF and HDL (P = 0.007). The serum levels of IFN-γ and TNF-α were positively associated with serum TG (P = 0.018 and 0.006, respectively).
Conclusions:
There are associations between various pro-and anti-inflammatory cytokines in serum and several anthropometric measurements.
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