STATE OF THE ART PAPER
Multisystem inflammatory syndrome in adults hospitalizations in the United States; evaluating patient characteristics, COVID-19 associations, and mortality
1
Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, USA
2
Dow University of Health Sciences, Karachi, Pakistan
3
Guru Gobind Singh Medical College, Faridkot, India
4
Independent Researcher, United States
5
Rawalpindi Medical University, Pakistan
6
Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur, India
7
Department of Internal Medicine, University of California, Riverside, US
8
Department of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV,
Las Vegas, US
9
Independent Researcher, Mauritius
10
Royal Brompton Hospital, London, UK
11
Northumbria Healthcare NHS Foundation Trust
These authors had equal contribution to this work
Submission date: 2024-07-28
Acceptance date: 2024-09-05
Publication date: 2024-09-16
Corresponding author
Nomesh Kumar
Department of Internal Medicine, Detroit Medical Center/ Wayne State University, Detroit, USA
Department of Internal Medicine, Detroit Medical Center/ Wayne State University, Detroit, USA
Arch Med Sci Atheroscler Dis 2024;9(1):165-170
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims to elucidate the demographics and clinical characteristics of MIS-A, aiding in timely diagnosis and management.
Methods:
Utilizing the National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A and non-MIS-A groups. Baseline characteristics and comorbidities, the association with COVID-19, post-COVID-19 syndrome, and personal history of COVID-19, as well as impact on mortality were studied.
Results:
We identified 2,730 adults with MIS-A. MIS-A was linked with active COVID-19 infection (aOR = 27.436, p < 0.001), post-COVID-19 syndrome (aOR = 32.766, p < 0.001), personal history of COVID-19 (aOR = 2.963, p < 0.001), and an increased mortality (aOR = 3.743, p < 0.001).
Conclusions:
Using data adjusted for confounding variables, MIS-A was found to be associated with active and past COVID-19, and a greater mortality rate when compared to non-MIS-A patients.
Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims to elucidate the demographics and clinical characteristics of MIS-A, aiding in timely diagnosis and management.
Methods:
Utilizing the National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A and non-MIS-A groups. Baseline characteristics and comorbidities, the association with COVID-19, post-COVID-19 syndrome, and personal history of COVID-19, as well as impact on mortality were studied.
Results:
We identified 2,730 adults with MIS-A. MIS-A was linked with active COVID-19 infection (aOR = 27.436, p < 0.001), post-COVID-19 syndrome (aOR = 32.766, p < 0.001), personal history of COVID-19 (aOR = 2.963, p < 0.001), and an increased mortality (aOR = 3.743, p < 0.001).
Conclusions:
Using data adjusted for confounding variables, MIS-A was found to be associated with active and past COVID-19, and a greater mortality rate when compared to non-MIS-A patients.
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