CLINICAL RESEARCH
Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: an 8-week, open-label, single-arm pilot study
 
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Submission date: 2018-07-28
Final revision date: 2018-08-07
Acceptance date: 2018-08-10
Publication date: 2018-11-14
 
Arch Med Sci Atheroscler Dis 2018;3(1):137–141
 
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ABSTRACT
Introduction:
The present open-label, single-arm pilot study sought to evaluate the effects of a nutraceutical combination containing fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia.

Material and methods:
Forty patients with mild-to-moderate hypercholesterolemia received the nutraceutical combination containing fermented red rice, liposomal berberine, and curcumin, once a day for 8 weeks. The study outcomes included changes from baseline in lipid (total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), oxidized low-density lipoprotein (oxLDL), high-density-lipoprotein cholesterol (HDL-C), and triglycerides (TG)) and inflammatory parameters (high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor- (TNF-)).

Results:
Compared with baseline, the nutraceutical combination produced a statistically significant reduction of TC (–20.4%, p < 0.05), LDL-C (–27.6%, p < 0.05), oxLDL (–23.2%, p < 0.05), and TG (–17.9%, p < 0.05). We also observed a reduction from baseline for hs-CRP (–15.4%, p < 0.05) and TNF- (–14.3%, p < 0.05). The treatment was well tolerated and none of the patients discontinued treatment due to adverse effects. No cases of myalgia or musculoskeletal system disorders were observed.

Conclusions:
The nutraceutical combination of fermented red rice, liposomal berberine, and curcumin improves lipid profile and reduces markers of inflammation in low-risk dyslipidemic patients, with potential implications for primary prevention of cardiovascular disease.

ISSN:2451-0629