STATE OF THE ART PAPER
Non-traumatic and non-drug-induced rhabdomyolysis
 
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1
Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
2
Cardiology Department, Tzanio Hospital, Piraeus, Greece
3
Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece
4
First Department of Internal Medicine, Division of Endocrinology-Metabolism, Diabetes Center, AHEPA University Hospital, Thessaloniki, Greece
Submission date: 2019-08-08
Final revision date: 2019-10-07
Acceptance date: 2019-10-10
Publication date: 2019-12-02
 
Arch Med Sci Atheroscler Dis 2019;4(1):252–263
 
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ABSTRACT
Rhabdomyolysis (RM), a fortunately rare disease of the striated muscle cells, is a complication of non-traumatic (congenital (glycogen storage disease, discrete mitochondrial myopathies and various muscular dystrophies) or acquired (alcoholic myopathy, systemic diseases, arterial occlusion, viral illness or bacterial sepsis)) and traumatic conditions. Additionally, RM can occur in some individuals under specific circumstances such as toxic substance use and illicit drug abuse. Lipid-lowering drugs in particular are capable of causing RM. This comprehensive review will focus on non-traumatic and non-drug-induced RM. Moreover, the pathology of RM, its clinical manifestation and biochemical effects, and finally its management will be discussed.
ISSN:2451-0629