STATE OF THE ART PAPER
History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology
1
Department of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, Kaiserslautern, Germany
2
Department of General Surgery, Patras University Hospital, Patras, Greece
3
Department of Thoracic Surgery and Thoracic Endoscopy, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen Essen, Germany
4
Medical Physics Department, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece
5
Department of Cardiothoracic Surgery, General Hospital of Nicosia, Nicosia, Cyprus
6
Department of Cardiac Surgery, Ippokrateion Hospital, Athens, Greece
7
Department of Cardiothoracic Surgery, Patras University Hospital, Patras, Greece
Submission date: 2024-05-01
Acceptance date: 2024-05-04
Publication date: 2024-05-29
Arch Med Sci Atheroscler Dis 2024;9(1):109-121
KEYWORDS
isolated heart perfusioncardiovascular researchLangendorff heartcardiac physiologypharmacological testingdisease modeling
TOPICS
ABSTRACT
The isolated heart perfusion model, a fundamental tool in cardiovascular research, has evolved significantly since its inception in the late 19th century. This review traces the development of the isolated heart model, from its early adaptations by pioneers such as Langendorff and Starling to modern advancements by researchers like Morgan and Neely. We discuss the various applications of the model in pharmacological testing, disease modeling, and educational settings, emphasizing its crucial role in understanding cardiac function and disease mechanisms. Recent technological enhancements, including high-resolution imaging, integration with bioengineering, and advanced genomic and proteomic analyses, have significantly broadened the capabilities of these models. Looking forward, we explore potential future developments such as the integration of precision medicine, stem cell research, and artificial intelligence, which promise to revolutionize the use of isolated heart perfusion models. This review highlights the model’s crucial role in bridging experimental research and clinical applications.
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| ISSN: | 2451-0629 |
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